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Synonyms: pyrazolopyrimidine 1
Compound class: Synthetic organic
Comment: PP1 is a multi-kinase inhibitor.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Bain J, McLauchlan H, Elliott M, Cohen P. (2003)
The specificities of protein kinase inhibitors: an update.
Biochem J, 371 (Pt 1): 199-204. [PMID:12534346]
2. Hanke JH, Gardner JP, Dow RL, Changelian PS, Brissette WH, Weringer EJ, Pollok BA, Connelly PA. (1996)
Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation.
J Biol Chem, 271 (2): 695-701. [PMID:8557675]
3. Tatton L, Morley GM, Chopra R, Khwaja A. (2003)
The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases.
J Biol Chem, 278 (7): 4847-53. [PMID:12475982]
4. Yagi YI, Abe K, Ikebukuro K, Sode K. (2009)
Kinetic mechanism and inhibitor characterization of WNK1 kinase.
Biochemistry, 48 (43): 10255-66. [PMID:19739668]