PWT2-N/OFQ   Click here for help

GtoPdb Ligand ID: 8865

Comment: PWT2-N/OFQ was generated using a novel technology termed 'peptide welding' (PWT) [1]. In this instance nociceptin and orphanin FQ peptides are welded onto a Cyclam core molecule, the complete structure of which is shown in [2].
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1. Guerrini R, Marzola E, Trapella C, Pela' M, Molinari S, Cerlesi MC, Malfacini D, Rizzi A, Salvadori S, Calo' G. (2014)
A novel and facile synthesis of tetra branched derivatives of nociceptin/orphanin FQ.
Bioorg Med Chem, 22 (14): 3703-12. [PMID:24878361]
2. Rizzi A, Malfacini D, Cerlesi MC, Ruzza C, Marzola E, Bird MF, Rowbotham DJ, Salvadori S, Guerrini R, Lambert DG et al.. (2014)
In vitro and in vivo pharmacological characterization of nociceptin/orphanin FQ tetrabranched derivatives.
Br J Pharmacol, 171 (17): 4138-53. [PMID:24903280]