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Compound class: Peptide or derivative
Comment: PWT2-N/OFQ was generated using a novel technology termed 'peptide welding' (PWT) . In this instance nociceptin and orphanin FQ peptides are welded onto a Cyclam core molecule, the complete structure of which is shown in .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Guerrini R, Marzola E, Trapella C, Pela' M, Molinari S, Cerlesi MC, Malfacini D, Rizzi A, Salvadori S, Calo' G. (2014)
A novel and facile synthesis of tetra branched derivatives of nociceptin/orphanin FQ.
Bioorg Med Chem, 22 (14): 3703-12. [PMID:24878361]
2. Rizzi A, Malfacini D, Cerlesi MC, Ruzza C, Marzola E, Bird MF, Rowbotham DJ, Salvadori S, Guerrini R, Lambert DG et al.. (2014)
In vitro and in vivo pharmacological characterization of nociceptin/orphanin FQ tetrabranched derivatives.
Br J Pharmacol, 171 (17): 4138-53. [PMID:24903280]