PWT2-N/OFQ   Click here for help

GtoPdb Ligand ID: 8865

Comment: PWT2-N/OFQ was generated using a novel technology termed 'peptide welding' (PWT) [1]. In this instance nociceptin and orphanin FQ peptides are welded onto a Cyclam core molecule, the complete structure of which is shown in [2].
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Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
NOP receptor Hs Agonist Agonist 10.3 pKi - 2
pKi 10.3 [2]
NOP receptor Hs Agonist Agonist 8.8 pEC50 - 2
pEC50 8.8 [2]
Description: Stimulation of GTP-γ35S binding