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Synonyms: CD 2314 | CD-2314
Compound class: Synthetic organic
Comment: CD2314 is a potent and selective retinoic acid receptor β (RARβ) agonist [1-2].
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Spanjaard RA, Ikeda M, Lee PJ, Charpentier B, Chin WW, Eberlein TJ. (1997)
Specific activation of retinoic acid receptors (RARs) and retinoid X receptors reveals a unique role for RARgamma in induction of differentiation and apoptosis of S91 melanoma cells.
J Biol Chem, 272 (30): 18990-9. [PMID:9228081]
2. Zhao X, Graves C, Ames SJ, Fisher DE, Spanjaard RA. (2009)
Mechanism of regulation and suppression of melanoma invasiveness by novel retinoic acid receptor-gamma target gene carbohydrate sulfotransferase 10.
Cancer Res, 69 (12): 5218-25. [PMID:19470764]