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Synonyms: fenoximone | MDL 17,043 | MDL-17,043 | MDL-17043 | Perfan®
enoximone is an approved drug (UK)
Compound class: Synthetic organic
Comment: Enoximone is a selective phosphodiesterase inhibitor, targeting PDE3 subtypes . It is a cardiotonic agent [1,3].
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: enoximone
1. Dage RC, Roebel LE, Hsieh CP, Weiner DL, Woodward JK. (1982)
Cardiovascular properties of a new cardiotonic agent: MDL 17,043 (1.3-dihydro-4-methyl-5-[4-(methylthio)-benzoyl]-2H-imidazol-2-one).
J Cardiovasc Pharmacol, 4 (3): 500-8. [PMID:6177949]
2. el Allaf D, D'Orio V, Carlier J. (1984)
The new inotropic phosphodiesterase inhibitors.
Arch Int Physiol Biochim, 92 (4): S69-79. [PMID:6085243]
3. Roebel LE, Dage RC, Cheng HC, Woodward JK. (1982)
Characterization of the cardiovascular activities of a new cardiotonic agent, MDL 17043 (1,3-dihydro-4-methyl-5-[4-(methylthio)-benzoyl]-2H-imidazole-2-one).
J Cardiovasc Pharmacol, 4 (5): 721-9. [PMID:6182401]
4. Venuti MC, Jones GH, Alvarez R, Bruno JJ. (1987)
Inhibitors of cyclic AMP phosphodiesterase. 2. Structural variations of N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro- 2-oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide (RS-82856).
J Med Chem, 30 (2): 303-18. [PMID:3027339]
5. Weber KT, Janicki JS, Jain MC. (1986)
Enoximone (MDL 17,043), a phosphodiesterase inhibitor, in the treatment of advanced, unstable chronic heart failure.
J Heart Transplant, 5 (2): 105-12. [PMID:2956397]