Compound class:
Synthetic organic
Comment: Partially selective GC-B (NPR-B) antagonist that mediates a strong reduction of the maximum cGMP production and no changes of the EC50 values for CNP
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References |
1. Bach T, Bergholtz S, Riise J, Qvigstad E, Skomedal T, Osnes JB, Levy FO. (2014)
Identification of small molecule NPR-B antagonists by high throughput screening--potential use in heart failure. Naunyn Schmiedebergs Arch Pharmacol, 387 (1): 5-14. [PMID:24297249] |