sauvagine   Click here for help

GtoPdb Ligand ID: 918

Comment: Isolated from the skin of the Sauvage's leaf frog (Phyllomedusa sauvagei)
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1. Dautzenberg FM, Dietrich K, Palchaudhuri MR, Spiess J. (1997)
Identification of two corticotropin-releasing factor receptors from Xenopus laevis with high ligand selectivity: unusual pharmacology of the type 1 receptor.
J. Neurochem., 69 (4): 1640-9. [PMID:9326293]
2. Dautzenberg FM, Gutknecht E, Van der Linden I, Olivares-Reyes JA, Dürrenberger F, Hauger RL. (2004)
Cell type specific calcium signaling by corticotropin-releasing factor type 1 (CRF1) and 2a (CRF2(a)) receptors: Gq coupling in human embryonic kidney 293 but not SK-N-MC neuroblastoma cells.
Biochem Pharmacol., 68: 1833-1844. [PMID:15450949]
3. Dautzenberg FM, Py-Lang G, Higelin J, Fischer C, Wright MB, Huber G. (2001)
Different binding modes of amphibian and human corticotropin-releasing factor type 1 and type 2 receptors: evidence for evolutionary differences.
J. Pharmacol. Exp. Ther., 296 (1): 113-20. [PMID:11123370]
4. Donaldson CJ, Sutton SW, Perrin MH, Corrigan AZ, Lewis KA, Rivier JE, Vaughan JM, Vale WW. (1996)
Cloning and characterization of human urocortin.
Endocrinology, 137 (5): 2167-70. [PMID:8612563]
5. Perrin MH, Sutton SW, Cervini LA, Rivier JE, Vale WW. (1999)
Comparison of an agonist, urocortin, and an antagonist, astressin, as radioligands for characterization of corticotropin-releasing factor receptors.
J. Pharmacol. Exp. Ther., 288 (2): 729-34. [PMID:9918582]
6. Vaughan J, Donaldson C, Bittencourt J, Perrin MH, Lewis K, Sutton S, Chan R, Turnbull AV, Lovejoy D, Rivier C et al.. (1995)
Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor.
Nature, 378 (6554): 287-92. [PMID:7477349]