Synonyms: Example 130 [US20140194408] | GDC-0853 | GDC0853 | RG-7845 | RG7845
Compound class:
Synthetic organic
Comment: Fenebrutinib (RG7845, GDC-0853) is a Bruton's tyrosine kinase (BTK) inhibitor, under investigation for therapeutic potential in difficult-to-treat autoimmune diseases. The compound is claimed in patent WO2013067274 [2].
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References |
1. Akinleye A, Chen Y, Mukhi N, Song Y, Liu D. (2013)
Ibrutinib and novel BTK inhibitors in clinical development. J Hematol Oncol, 6: 59. [PMID:23958373] |
2. Crawford JJ, Ortwine DF, Wei B, Young WB. (2013)
Heteroaryl pyridone and aza-pyridone compounds as inhibitors of btk activity. Patent number: WO2013067274. Assignee: Genentech, Inc.. Priority date: 03/11/2011. Publication date: 10/05/2013. |
3. Musumeci F, Sanna M, Greco C, Giacchello I, Fallacara AL, Amato R, Schenone S. (2017)
Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors. Expert Opin Ther Pat, 27 (12): 1305-1318. [PMID:28705083] |