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Synonyms: BBAC | compound 18 [PMID: 18207395] | TCS-1102
Compound class: Synthetic organic
Comment: TCS 1102 is a dual orexin antagonist, with potent in vivo central activity in a pharmacodynamic model of orexin activity .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Bergman JM, Roecker AJ, Mercer SP, Bednar RA, Reiss DR, Ransom RW, Meacham Harrell C, Pettibone DJ, Lemaire W, Murphy KL et al.. (2008)
Proline bis-amides as potent dual orexin receptor antagonists.
Bioorg Med Chem Lett, 18 (4): 1425-30. [PMID:18207395]