PP2   Click here for help

GtoPdb Ligand ID: 9404

Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: PP2 is a non-selective (pan) inhibitor of Src family tyrosine kinases, used widely to study the biological roles of Src kinases [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 69.62
Molecular weight 301.11
XLogP 4.08
No. Lipinski's rules broken 0
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Canonical SMILES Clc1ccc(cc1)c1nn(c2c1c(N)ncn2)C(C)(C)C
Isomeric SMILES Clc1ccc(cc1)c1nn(c2c1c(N)ncn2)C(C)(C)C
InChI InChI=1S/C15H16ClN5/c1-15(2,3)21-14-11(13(17)18-8-19-14)12(20-21)9-4-6-10(16)7-5-9/h4-8H,1-3H3,(H2,17,18,19)
1. Hanke JH, Gardner JP, Dow RL, Changelian PS, Brissette WH, Weringer EJ, Pollok BA, Connelly PA. (1996)
Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation.
J Biol Chem, 271 (2): 695-701. [PMID:8557675]