Synonyms: SK&F-83566 | SK-83566 | SK83566
Compound class:
Synthetic organic
Comment: SKF-83566 is a dopamine receptor antagonist with selectivity for D1/D5 compared to D2 [1,3].
Note we have corrected the name of this ligand from SKF-83556 to SKF-83566. SKF-83566 (30 μM) is reported to inhibit adenylyl cyclase 2 (AC2) activity by ~95% in vitro [2]. ![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Bakthavachalam V, Baindur N, Madras BK, Neumeyer JL. (1991)
Fluorescent probes for dopamine receptors: synthesis and characterization of fluorescein and 7-nitrobenz-2-oxa-1,3-diazol-4-yl conjugates of D-1 and D-2 receptor ligands. J Med Chem, 34 (11): 3235-41. [PMID:1956042] |
2. Conley JM, Brand CS, Bogard AS, Pratt EP, Xu R, Hockerman GH, Ostrom RS, Dessauer CW, Watts VJ. (2013)
Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor. J Pharmacol Exp Ther, 347 (2): 276-87. [PMID:24008337] |
3. Sunahara RK, Guan HC, O'Dowd BF, Seeman P, Laurier LG, Ng G, George SR, Torchia J, Van Tol HH, Niznik HB. (1991)
Cloning of the gene for a human dopamine D5 receptor with higher affinity for dopamine than D1. Nature, 350 (6319): 614-9. [PMID:1826762] |