RgIA4   Click here for help

GtoPdb Ligand ID: 9472

Comment: RgIA4 is an α-conotoxin RgIA derivative, designed for potential pain therapy. Functionally it is a potent and selective α9α10 nicotinic acetylcholine receptor (nAChR) antagonist [1].
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1. Romero HK, Christensen SB, Di Cesare Mannelli L, Gajewiak J, Ramachandra R, Elmslie KS, Vetter DE, Ghelardini C, Iadonato SP, Mercado JL et al.. (2017)
Inhibition of α9α10 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain.
Proc Natl Acad Sci USA, 114 (10): E1825-E1832. [PMID:28223528]