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GtoPdb Ligand ID: 9531

Synonyms: carbon monoxide
Compound class: Inorganic
Comment: Carbon monoxide is naturally produced by the action of heme oxygenase 1 and 2, which convert heme into biliverdin and carbon monoxide, utilizing NADPH as cofactor. Carbon monoxide has received a great deal of clinical attention as a biological regulator. Clinical trials of small amounts of carbon monoxide as a drug are ongoing. CO-releasing molecules (CORMs) are in development for their potential antioxidant, anti-inflammatory, and anti-tumor properties [1].
1. Motterlini R, Mann BE, Foresti R. (2005)
Therapeutic applications of carbon monoxide-releasing molecules.
Expert Opin Investig Drugs, 14 (11): 1305-18. [PMID:16255672]