Synonyms: 10-tosyl-10H-phenoxazine | compound 21 [PMID: 23075067]
Compound class:
Synthetic organic
Comment: PSB-12062 is a P2X4 receptor antagonist with an allosteric mode of action [1].
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Hernandez-Olmos V, Abdelrahman A, El-Tayeb A, Freudendahl D, Weinhausen S, Müller CE. (2012)
N-substituted phenoxazine and acridone derivatives: structure-activity relationships of potent P2X4 receptor antagonists. J Med Chem, 55 (22): 9576-88. [PMID:23075067] |
2. Jacobson KA, Müller CE. (2016)
Medicinal chemistry of adenosine, P2Y and P2X receptors. Neuropharmacology, 104: 31-49. [PMID:26686393] |
3. North RA, Jarvis MF. (2013)
P2X receptors as drug targets. Mol Pharmacol, 83 (4): 759-69. [PMID:23253448] |