Ligand id: 9640

Name: rontalizumab

1. Anan C, Kim JK, Presta LG, Stewart T. (2009)
Anti-interferon-α antibodies.
Patent number: US7582445. Assignee: Genentech, Inc.. Priority date: 22/02/2001. Publication date: 01/09/2009.
2. Chuntharapai A, Lai J, Huang X, Gibbs V, Kim KJ, Presta LG, Stewart TA. (2001)
Characterization and humanization of a monoclonal antibody that neutralizes human leukocyte interferon: a candidate therapeutic for IDDM and SLE.
Cytokine, 15 (5): 250-60. [PMID:11594789]
3. Kalunian KC. (2016)
Interferon-targeted therapy in systemic lupus erythematosus: Is this an alternative to targeting B and T cells?.
Lupus, 25 (10): 1097-101. [PMID:27497254]
4. Kalunian KC, Merrill JT, Maciuca R, McBride JM, Townsend MJ, Wei X, Davis Jr JC, Kennedy WP. (2016)
A Phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-α) in patients with systemic lupus erythematosus (ROSE).
Ann. Rheum. Dis., 75 (1): 196-202. [PMID:26038091]
5. Maurer B, Bosanac I, Shia S, Kwong M, Corpuz R, Vandlen R, Schmidt K, Eigenbrot C. (2015)
Structural basis of the broadly neutralizing anti-interferon-α antibody rontalizumab.
Protein Sci., 24 (9): 1440-50. [PMID:26099203]