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Synonyms: 9F3v13 | RhuMAB IFNalpha | rhuMAb interferon-α
Compound class: Antibody
Comment: Rontalizumab is a humanized monoclonal antibody targeting interferon alpha (IFNα) that has immunomodulatory potential. It was humanized from a mouse monoclonal as described in , and peptide sequences of the antibody (identified as humanized 9F3v13) are claimed in Genentech patent US7582445 .
Rontalizumab is functionally similar to sifalimumab. Development of both of these anti-IFNα agents has been discontinued. Compare these with anifrolumab, which targets the type I interferon receptor (IFNAR1) rather than the ligand itself, and which has progressed to Phase 3 clinical trial.
A 3D X-ray structure of rontalizumab's Fab domain bound to IFNα2 has been published (PDB identifier 4Z5R) .
|Rontalizumab is broadly neutralizing of IFN-αs but not other Type I interferons .|
|Selectivity at ligand targets|
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