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Synonyms: compound 3 [PMID: 18642892]
Compound class: Synthetic organic
Comment: BML-281 is an experimental selective HDAC6/3 inhibitor , that has demonstrated anti-inflammatory activity in a murine model of colonic inflammation .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Do A, Reid RC, Lohman RJ, Sweet MJ, Fairlie DP, Iyer A. (2017)
An HDAC6 Inhibitor Confers Protection and Selectively Inhibits B-Cell Infiltration in DSS-Induced Colitis in Mice.
J. Pharmacol. Exp. Ther., 360 (1): 140-151. [PMID:27827303]
2. Kozikowski AP, Tapadar S, Luchini DN, Kim KH, Billadeau DD. (2008)
Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.
J. Med. Chem., 51 (15): 4370-3. [PMID:18642892]