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Compound class: Synthetic organic
Comment: JFD00064 is a non-peptidic inhibitor of aminopeptidase N (APN) . Unlike other APN inhibitors it is non-competitive with respect to the enzyme's zinc binding domain.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Pascual I, Valiente PA, García G, Valdés-Tresanco ME, Arrebola Y, Díaz L, Bounaadja L, Uribe RM, Pacheco MC, Florent I et al.. (2017)
Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN).
Biochimie, 142: 216-225. [PMID:28964831]