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Synonyms: GI 254023X | GI-254023X
Compound class: Synthetic organic
Comment: GI254023X is an ADAM10-selective inhibitor . It can be used as a pharmacological tool to interrogate the relevance of ADAM10 sheddase activity in biological assays.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Hoettecke N, Ludwig A, Foro S, Schmidt B. (2010)
Improved synthesis of ADAM10 inhibitor GI254023X.
Neurodegener Dis, 7 (4): 232-8. [PMID:20197648]
2. Ludwig A, Hundhausen C, Lambert MH, Broadway N, Andrews RC, Bickett DM, Leesnitzer MA, Becherer JD. (2005)
Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.
Comb Chem High Throughput Screen, 8 (2): 161-71. [PMID:15777180]