Synonyms: BI 1935 | example 3 [WO2007067836]
Compound class:
Synthetic organic
Comment: BI-1935 is a potent and selective small molecule inhibitor of epoxide hydrolase 2 (a.k.a. soluble epoxide hydrolase, sEH). It is claimed as Example 3 in Boehringer Ingelheim's patent WO2007067836 [1].
This ligand is one of the compounds available from Boehringer Ingelheim's opnMe molecular library. Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Fleck RW, Guo X, Lo HY, Man CC. (2007)
Substituted pyrazole compounds useful as soluble epoxide hyrolase inhibitors. Patent number: WO2007067836. Assignee: Boehringer Ingelheim Int, Fleck RW, Guo X, Lo HY, Man CC. Priority date: 05/12/2005. Publication date: 15/11/2007. |
2. Taylor SJ, Soleymanzadeh F, Eldrup AB, Farrow NA, Muegge I, Kukulka A, Kabcenell AK, De Lombaert S. (2009)
Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett, 19 (20): 5864-8. [PMID:19758802] |
3. Yu Z, Xu F, Huse LM, Morisseau C, Draper AJ, Newman JW, Parker C, Graham L, Engler MM, Hammock BD et al.. (2000)
Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids. Circ Res, 87 (11): 992-8. [PMID:11090543] |