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Synonyms: compound 67 [PMID: 22924688] | example 15 [WO2011008487]  | INCB 40093 | INCB40093
Compound class: Synthetic organic
Comment: Dezapelisib (INCB 40093) is a potent and selective PIK3δ inhibitor that was being developed as a potential therapy for B cell malignancies . Claimed as example 15 in patent WO2011008487, although only binned IC50 values are contained in this patent document .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Cushing TD, Metz DP, Whittington DA, McGee LR. (2012)
PI3Kδ and PI3Kγ as targets for autoimmune and inflammatory diseases.
J Med Chem, 55 (20): 8559-81. [PMID:22924688]
2. Li Y-L, Metcalf BW, Combs AP. (2011)
Pyrimidinones as PI3K inhibitors.
Patent number: WO2011008487. Assignee: Incyte Corporation. Priority date: 29/06/2009. Publication date: 20/01/2011.