liver enriched antimicrobial peptide 2   Click here for help

GtoPdb Ligand ID: 9734

Abbreviated name: LEAP2
Immunopharmacology Ligand
Comment: LEAP2 is an endogenous peptide with antimicrobial properties, that is part of the humoral immune response to microbes. It is expressed in the liver. LEAP2 has also been identified as an endogenous antagonist of the appetite-stimulatory hormone, ghrelin, that is secreted in the stomach and which acts via the pituitary/hypothalamic ghrelin receptor (growth hormone secretagogue receptor, or GHSR) [1].
Species: Human
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1. Ge X, Yang H, Bednarek MA, Galon-Tilleman H, Chen P, Chen M, Lichtman JS, Wang Y, Dalmas O, Yin Y et al.. (2018)
LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor.
Cell Metab, 27 (2): 461-469.e6. [PMID:29233536]