emicizumab   Click here for help

GtoPdb Ligand ID: 9744

Synonyms: ACE-910 | ACE910 | emicizumab-kxwh | Hemlibra® | RG6013
Approved drug
emicizumab is an approved drug (FDA (2017), EMA (2018))
Compound class: Antibody
Comment: Emicizumab, is a humanised bispecific antibody that binds blood coagulation factors IXa and X and acts as a factor VIII mimetic to bring about activation of factor X, and promote coagulation [2-3,5]. In essence, emicizumab works by bridging between coagulation factors IX and X and is the first-in-class drug for haemophilia A prevention with this mechanism of action.
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1. FDA. 
FDA approves emicizumab-kxwh for prevention and reduction of bleeding in patients with hemophilia A with factor VIII inhibitors.
Accessed on 03/01/2018. Modified on 03/01/2018. fda.gov, https://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm585650.htm
2. Kitazawa T, Esaki K, Tachibana T, Ishii S, Soeda T, Muto A, Kawabe Y, Igawa T, Tsunoda H, Nogami K et al.. (2017)
Factor VIIIa-mimetic cofactor activity of a bispecific antibody to factors IX/IXa and X/Xa, emicizumab, depends on its ability to bridge the antigens.
Thromb Haemost, 117 (7): 1348-1357. [PMID:28451690]
3. Muto A, Yoshihashi K, Takeda M, Kitazawa T, Soeda T, Igawa T, Sakamoto Y, Haraya K, Kawabe Y, Shima M et al.. (2014)
Anti-factor IXa/X bispecific antibody (ACE910): hemostatic potency against ongoing bleeds in a hemophilia A model and the possibility of routine supplementation.
J Thromb Haemost, 12 (2): 206-213. [PMID:24735117]
4. Oldenburg J, Mahlangu JN, Kim B, Schmitt C, Callaghan MU, Young G, Santagostino E, Kruse-Jarres R, Negrier C, Kessler C et al.. (2017)
Emicizumab Prophylaxis in Hemophilia A with Inhibitors.
N Engl J Med, 377 (9): 809-818. [PMID:28691557]
5. Sampei Z, Igawa T, Soeda T, Okuyama-Nishida Y, Moriyama C, Wakabayashi T, Tanaka E, Muto A, Kojima T, Kitazawa T et al.. (2013)
Identification and multidimensional optimization of an asymmetric bispecific IgG antibody mimicking the function of factor VIII cofactor activity.
PLoS ONE, 8 (2): e57479. [PMID:23468998]
6. Yousphi AS, Bakhtiar A, Cheema MA, Nasim S, Ullah W. (2019)
Acquired Hemophilia A: A Rare but Potentially Fatal Bleeding Disorder.
Cureus, 11 (8): e5442. [PMID:31632887]