MK6-83

Ligand id: 9783

Name: MK6-83

Structure and Physico-chemical Properties

2D Structure
Click here for structure editor
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 86.03
Molecular weight 336.1
XLogP 2.82
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Chen CC, Keller M, Hess M, Schiffmann R, Urban N, Wolfgardt A, Schaefer M, Bracher F, Biel M, Wahl-Schott C et al.. (2014)
A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV.
Nat Commun, 5: 4681. [PMID:25119295]
2. Grimm C. (2016)
Endolysosomal Cation Channels as Therapeutic Targets—Pharmacology of TRPML Channels.
Messenger, 5 (1/2): 30-36.