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Compound class: Synthetic organic
Comment: Potent MOPR agonist and DOPR antagonist; a MOP/DOP bifunctional opioid.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Dietis N, McDonald J, Molinari S, Calo G, Guerrini R, Rowbotham DJ, Lambert DG. (2012)
Pharmacological characterization of the bifunctional opioid ligand H-Dmt-Tic-Gly-NH-Bzl (UFP-505).
Br J Anaesth, 108 (2): 262-70. [PMID:22194444]
2. Dietis N, Niwa H, Tose R, McDonald J, Ruggieri V, Filaferro M, Vitale G, Micheli L, Ghelardini C, Salvadori S et al.. (2018)
In vitro and in vivo characterization of the bifunctional μ and δ opioid receptor ligand UFP-505.
Br J Pharmacol, 175 (14): 2881-2896. [PMID:29524334]