- Advanced search
- Immuno Portal
- Malaria Portal
Synonyms: compound 19 [Hatcher et al., 2018]
Compound class: Synthetic organic
Comment: JH-VIII-49 is a synthetically produced analogue of the natural product cortistatin A . Like cortistatin A, JH-VIII-49 is a potent inhibitor of CDK8. Inhibition of CDK8 by small molecular agents is being explored as a novel mechanism for cancer therapy.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Hatcher JM, Wang ES, Johannessen L, Kwiatkowski N, Sim T, Gray NS. (2018)
Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8.
ACS Med Chem Lett, 9 (6): 540-545. [PMID:29937979]