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Synonyms: inhibitor 23 [PMID: 29614224]
Compound class: Synthetic organic
Comment: MMPA is an orally bioavailable dual inhibitor of soluble epoxide hydrolase (sEH) and phosphodiesterase 4 (PDE4) . It was designed to provide enhanced analgesia for the treatment of inflammatory pain. MMPA can be described as a polypharmacological agent, i.e. a single molecule with at least two pharmacophores in a novel molecular design.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Blöcher R, Wagner KM, Gopireddy RR, Harris TR, Wu H, Barnych B, Hwang SH, Xiang YK, Proschak E, Morisseau C et al.. (2018)
Orally Available Soluble Epoxide Hydrolase/Phosphodiesterase 4 Dual Inhibitor Treats Inflammatory Pain.
J Med Chem, 61 (8): 3541-3550. [PMID:29614224]