Synonyms: GBR 12909 | GBR-12909 | GBR12909
Compound class:
Synthetic organic
Comment: Competitive inhibitor of dopamine uptake, binds to the target site on the dopamine transporter (DAT). Also a potent sigma receptor ligand.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Andersen PH. (1989)
The dopamine inhibitor GBR 12909: selectivity and molecular mechanism of action. Eur J Pharmacol, 166 (3): 493-504. [PMID:2530094] |
2. Contreras PC, Bremer ME, Rao TS. (1990)
GBR-12909 and fluspirilene potently inhibited binding of [3H] (+)3-PPP to sigma receptors in rat brain. Life Sci, 47 (22): PL133-7. [PMID:1980329] |
3. Heikkila RE, Manzino L. (1984)
Behavioral properties of GBR 12909, GBR 13069 and GBR 13098: specific inhibitors of dopamine uptake. Eur J Pharmacol, 103 (3-4): 241-8. [PMID:6237922] |
4. Melia KF, Spealman RD. (1991)
Pharmacological characterization of the discriminative-stimulus effects of GBR 12909. J Pharmacol Exp Ther, 258 (2): 626-32. [PMID:1678014] |