NVP-TAE684

Ligand id: 5714

Name: NVP-TAE684

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 9
Topological polar surface area 111.31
Molecular weight 613.26
XLogP 5.55
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Large-scale screening data

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,4

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action Value Parameter
c-ros oncogene 1, receptor tyrosine kinase ROS1 Hs Inhibitor Inhibition 9.3 pKd
unc-51 like autophagy activating kinase 1 ULK1 Hs Inhibitor Inhibition 9.1 pKd
bone morphogenetic protein receptor type IB BMPR1B Hs Inhibitor Inhibition 9.1 pKd
leucine rich repeat kinase 2 LRRK2(G2019S) Hs Inhibitor Inhibition 9.1 pKd
polo like kinase 4 PLK4 Hs Inhibitor Inhibition 9.0 pKd
leukocyte receptor tyrosine kinase LTK Hs Inhibitor Inhibition 9.0 pKd
ALK receptor tyrosine kinase ALK Hs Inhibitor Inhibition 9.0 pKd
protein tyrosine kinase 2 FAK Hs Inhibitor Inhibition 9.0 pKd
protein tyrosine kinase 2 beta PYK2 Hs Inhibitor Inhibition 9.0 pKd
NUAK family, SNF1-like kinase, 2 SNARK Hs Inhibitor Inhibition 8.9 pKd
Displaying the top 10 targets  View all targets in screen »