AG 9   Click here for help

GtoPdb Ligand ID: 5917

Synonyms: AG-9 | AG9 | tyrphostin 1 | tyrphostin A1
Compound class: Synthetic organic
Comment: This is compound 1 in [3].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 56.81
Molecular weight 184.06
XLogP 1.57
No. Lipinski's rules broken 0
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Canonical SMILES COc1ccc(cc1)C=C(C#N)C#N
Isomeric SMILES COc1ccc(cc1)C=C(C#N)C#N
InChI InChI=1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
p21 (RAC1) activated kinase 2 PAK2/PAK2 Hs Inhibitor Inhibition 58.1 106.0 99.0
microtubule affinity regulating kinase 3 nd/MARK3 Hs Inhibitor Inhibition 72.5
3-phosphoinositide dependent protein kinase 1 PDK1/PDK1(PDPK1) Hs Inhibitor Inhibition 72.6 113.0 111.0
fibroblast growth factor receptor 4 FGFR4/FGFR4 Hs Inhibitor Inhibition 74.5 112.0 103.0
nemo like kinase NLK/NLK Hs Inhibitor Inhibition 77.0 95.0 86.0
protein tyrosine kinase 2 beta Pyk2/PYK2 Hs Inhibitor Inhibition 78.8 133.0 91.0
unc-51 like kinase 3 ULK3/ULK3 Hs Inhibitor Inhibition 79.6 103.0 95.0
MAPK interacting serine/threonine kinase 2 Mnk2/MNK2 Hs Inhibitor Inhibition 80.8 111.0 109.0
cyclin dependent kinase 5 CDK5-p25/CDK5-p25 Hs Inhibitor Inhibition 81.9 90.0 99.0
homeodomain interacting protein kinase 4 nd/HIPK1 Hs Inhibitor Inhibition 82.6
Displaying the top 10 targets  View all targets in screen »