MEK1/2 inhibitor   Click here for help

GtoPdb Ligand ID: 6008

Synonyms: SL-327 | SL327
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 101.13
Molecular weight 335.07
XLogP 3.74
No. Lipinski's rules broken 0
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Canonical SMILES N#CC(=C(Sc1ccc(cc1)N)N)c1ccccc1C(F)(F)F
Isomeric SMILES N#C/C(=C(\Sc1ccc(cc1)N)/N)/c1ccccc1C(F)(F)F
InChI InChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

Reference: 1,3

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
WEE1 G2 checkpoint kinase nd/WEE1 Hs Inhibitor Inhibition 73.8
NUAK family, SNF1-like kinase, 2 nd/SNARK(NUAK2) Hs Inhibitor Inhibition 75.0
MET proto-oncogene, receptor tyrosine kinase Met/c-MET Hs Inhibitor Inhibition 77.2 98.0 90.0
MER proto-oncogene, tyrosine kinase Mer/c-MER Hs Inhibitor Inhibition 80.7 94.0 94.0
serine/threonine kinase 17a DRAK1/DRAK1(STK17A) Hs Inhibitor Inhibition 82.6 96.0 118.0
casein kinase 1 alpha 1 nd/CK1a1 Hs Inhibitor Inhibition 82.9
ribosomal protein S6 kinase A6 Rsk4/RSK4 Hs Inhibitor Inhibition 83.9 103.0 104.0
fms related receptor tyrosine kinase 1 Flt1/FLT1(VEGFR1) Hs Inhibitor Inhibition 85.4 83.0 38.0
calcium/calmodulin dependent protein kinase kinase 2 nd/CAMKK2 Hs Inhibitor Inhibition 85.5
mitogen-activated protein kinase kinase kinase kinase 2 GCK/GCK(MAP4K2) Hs Inhibitor Inhibition 85.7 69.0 72.0
Displaying the top 10 targets  View all targets in screen »