Synonyms: RB 101 | RB-101
Compound class:
Synthetic organic
Comment: RB101 is an enkephalinase inhibitor, that is used as a biological tool [2]. It is metabolically cleaved into two active components, each of which inhibits one of the zinc-metallopeptidase enkephalin-degrading enzymes, aminopeptidase N (APN; ANPEP) and neutral endopeptidase (neprilysin; official gene name membrane metalloendopeptidase MME) [1]. Aminopeptidase N/neprilysin inhibition with RB101 induces an elevation in the levels of the two endogenous enkephalins [Met]enkephalin and [Leu]enkephalin. Prodrugs with this mechanism of action are known collectively as Dual Enkephalinase Inhibitors, or DENKIs.
|
|