AM12   Click here for help

GtoPdb Ligand ID: 10292

Synonyms: 3,5,7-trihydroxy-2-(2-bromophenyl)-4H-chromen-4-one | AM-12
Compound class: Synthetic organic
Comment: AM12 is a synthetic derivative of the naturally occurring flavonol galangin. Like galangin it inhibits TRPC5-mediated calcium entry in to cells [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 0
Hydrogen bond donors 3
Rotatable bonds 1
Topological polar surface area 90.9
Molecular weight 347.96
XLogP 4.63
No. Lipinski's rules broken 0
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Canonical SMILES Oc1cc(O)c2c(c1)oc(c(c2=O)O)c1ccccc1Br
Isomeric SMILES Oc1cc(O)c2c(c1)oc(c(c2=O)O)c1ccccc1Br
InChI InChI=1S/C15H9BrO5/c16-9-4-2-1-3-8(9)15-14(20)13(19)12-10(18)5-7(17)6-11(12)21-15/h1-6,17-18,20H
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Molecular structure representations generated using Open Babel