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Compound class: Synthetic organic
Comment: Compound 21b is reported as a selective inhibitor of acid sphingomyelinase (ASM; SMPD1) . It crosses the blood-brain-barrier in a rat model and has predicted value as an antidepressant based on outcomes from in vivo behavioural models of depression.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖