Synonyms: LB100
Compound class:
Synthetic organic
Comment: LB-100 is a small molecule inhibitor of protein phosphatase 2A (PP2A) [3]. PP2A is a pivotal cellular switch that controls important events that impinge on cellular survival and death, such as cell cycle, apoptosis, and autophagy. PP2A acts on kinase substrates in a number of critical signal transduction pathways (including MAPK, Wnt, PI3K, NF&kappB, PKC, and Ca2+/calmodulin-dependent signalling pathways). PP2A is a validated oncology target. Studies have shown that LB-100 has anti-tumour activity [2] and can sensitise pancreatic cancer to chemotherapy [1] and radiotherapy [3].
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Molecular structure representations generated using Open Babel