Compound class:
Synthetic organic
Comment: The chemical structure for lirodegimod was re-drawn from proposed INN list 130 (Feb. 2024), in which the compound is described as a signal transducer and activator of transcription 3 (STAT3) degradation inducer with potential antineoplastic action. In the absence of published information about lirodegimod (March 2024), structural motifs suggest that this is a PROTAC class degrader with a VHL-binding moiety to target the bound STAT3 to the von Hippel-Lindau (VHL) Cullin 2-Ring ubiquitin ligase for proteasomal degradation, and a STAT3-binding domain that is structurally related to that of the declared STAT3 PROTAC SD-36. We will update this entry as soon as more information becomes freely available.
STAT3 degradation is a novel anti-cancer strategy, as an alternative to pharmacological inhibtion. |
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Molecular structure representations generated using Open Babel