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Synonyms: NutropinAq® | Omnitrope® | Saizen® | somatotropin
growth hormone 1 is an approved drug (FDA (1976), EMA (2001))
Compound class: Endogenous peptide in human, mouse or rat
Comment: Human growth hormone 1 (somatropin) produced by recombinant technology is an approved drug with the INN somatropin. This has identical 191-amino acid sequence to the endogenous hormone.
Biosimilar drug: The EMA approved the biosimilar named Omnitrope (Sandoz GmbH) in 2006.
View more information in the IUPHAR Pharmacology Education Project: growth hormone 1
|Selected 3D Structures|
|Phosphorylated serine at positions 106 and 150; deamidation of glutamine at position 137 and asparagine at position 152 by deterioration; disulphide bond formation between cysteine residues at positions 53 and 165, and 182 and 189|