growth hormone 1   

GtoPdb Ligand ID: 4943

Synonyms: NutropinAq® | Omnitrope® | Saizen® | somatotropin
growth hormone 1 is an approved drug (FDA (1976), EMA (2001))
Comment: Human growth hormone 1 (somatropin) produced by recombinant technology is an approved drug with the INN somatropin. This has identical 191-amino acid sequence to the endogenous hormone.

Biosimilar drug: The EMA approved the biosimilar named Omnitrope (Sandoz GmbH) in 2006.
Species: Human
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Peptide Sequence
FPTIPLSRLFDNAMLRAHRLHQLAFDTYQEFEEAYIPKEQKYSFLQNPQTSLCFSESIPTPSNREETQQKSNLELLRISL
LLIQSWLEPVQFLRSVFANSLVYGASDSNVYDLLKDLEEGIQTLMGRLEDGSPRTGQIFKQTYSKFDTNSHNDDALLKNY
GLLYCFRKDMDKVETFLRIVQCRSVEGSCGF
Selected 3D Structures
PDB Id: 1a22
Image of ligand 3D structure from RCSB PDB
Post-translational Modification
Phosphorylated serine at positions 106 and 150; deamidation of glutamine at position 137 and asparagine at position 152 by deterioration; disulphide bond formation between cysteine residues at positions 53 and 165, and 182 and 189