growth hormone 1   Click here for help

GtoPdb Ligand ID: 4943

Synonyms: NutropinAq® | Omnitrope® | Saizen® | somatotropin
Approved drug
growth hormone 1 is an approved drug (FDA (1976), EMA (2001))
Comment: Human growth hormone 1 (somatropin) produced by recombinant technology is an approved drug with the INN somatropin. This has identical 191-amino acid sequence to the endogenous hormone.

Biosimilar drug: The EMA approved the biosimilar named Omnitrope (Sandoz GmbH) in 2006.
Species: Human
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Natural/Endogenous Targets
Target
Growth hormone receptor
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Growth hormone receptor Primary target of this compound Ligand is endogenous in the given species Hs Agonist Agonist 9.0 pKd - 1
pKd 9.0 (Kd 9.1x10-10 M) [1]
Description: Binding affinity of recombinant GH1 (somatropin), to immobilised hGHR by SPR