insulin A chain   Click here for help

GtoPdb Ligand ID: 5013

Compound class: Endogenous peptide in human, mouse or rat
Comment: The A chain is 21 amino acids long, and relates to amino acids 90-110 of the pro-peptide sequence (P01308)
Species: Human
Is a component of
insulin
Peptide Sequence Click here for help
GIVEQCCTSICSLYQLENYCN
Gly-Ile-Val-Glu-Gln-Cys-Cys-Thr-Ser-Ile-Cys-Ser-Leu-Tyr-Gln-Leu-Glu-Asn-Tyr-Cys-Asn
Post-translational Modification
An internal disulphide bond forms between cysteine residues at positions 6 and 11. Two inter-chain disulphide bonds form with the insulin B chain to form the active peptide, between cysteine residues 7 of the B chain and 7 of the A chain, and 20 of the B chain and 19 of the A chain (numbering relative to the amino acid sequences of the individual peptide chains).