Synonyms: compound 1 (allosteric)
Compound class:
Synthetic organic
Comment: This compound is an allosteric inhibitor of PRMT3 [1]. The X-ray structure of compound 1 co-crystalised with PRMT shows binding at a novel site, distinct from the SAM (S-adenosyl methionime) and substrate peptide binding pockets [1]. The Protein Databank (PDB) ID for this structure is 3SMQ, with the ligand called TDU rather than compound 1.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Molecular structure representations generated using Open Babel