H3-CoA-20   Click here for help

GtoPdb Ligand ID: 7035

Comment: This compound is a member of a new class of histone acetyltransferase inhibitors known as bisubstrate inhibitors. It is formed from coenzyme A modified with peptide side chains of histone H3 sequence. See Lau et al (2000) for structural details [2]. The 3 dimensional structure of this compound in complex with GCN5 histone acetyltransferase (KAT2A) has been published [3]. For a review of compounds being investigated as modulators of histone-modifying enzyme activity see [1].
Click here for help
Peptide Sequence Click here for help
No information available.
Chemical Modification
H3-CoA-20 is a peptide conjugate; it consists of Co-enzyme A linked via an acetyl bridge to a 20 amino peptide derived from histone H3 sequence [2].