elosulfase alfa

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Ligands
elosulfase alfa

GtoPdb Ligand ID: 7392

Synonyms: BMN 110 | rhGALNS | Vimizim®

elosulfase alfa is an approved drug (EMA & FDA (2014))

Compound class: Peptide or derivative

Comment: Elosulfase alfa is a recombinant enzyme replacement therapy for galactosamine (N-acetyl)-6-sulfatase (GALNS, P34059) deficiency. The peptide is translated from the human cDNA expressed in CHO cells [1].

Summary
Biological activity
Clinical data
References
Structure

Peptide Sequence
MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCS PSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQFH150PLKHGFD EWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKT200GEANLTQIYLQEALDFIKRQARHHPFFLYWAVDA THAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTF EGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAAT LGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQ HQEALVPAQPQLNVCNWAVMNWAPPGCEKLGKCLTPPESIPKKCLWSH

Peptide Sequence

MAAVVAATRWWQLLLVLSAAGMGASGAPQPPNILLLLMDDMGWGDLGVYGEPSRETPNLDRMAAEGLLFPNFYSANPLCS
PSRAALLTGRLPIRNGFYTTNAHARNAYTPQEIVGGIPDSEQLLPELLKKAGYVSKIVGKWHLGHRPQFH150PLKHGFD
EWFGSPNCHFGPYDNKARPNIPVYRDWEMVGRYYEEFPINLKT200GEANLTQIYLQEALDFIKRQARHHPFFLYWAVDA
THAPVYASKPFLGTSQRGRYGDAVREIDDSIGKILELLQDLHVADNTFVFFTSDNGAALISAPEQGGSNGPFLCGKQTTF
EGGMREPALAWWPGHVTAGQVSHQLGSIMDLFTTSLALAGLTPPSDRAIDGLNLLPTLLQGRLMDRPIFYYRGDTLMAAT
LGQHKAHFWTWTNSWENFRQGIDFCPGQNVSGVTTHNLEDHTKLPLIFHLGRDPGERFPLSFASAEYQEALSRITSVVQQ
HQEALVPAQPQLNVCNWAVMNWAPPGCEKLGKCLTPPESIPKKCLWSH