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Synonyms: compound 23 [PMID: 18752942] 
Compound class: Synthetic organic
Comment: This compound was developed by Novartis Institute as an inhibitor of protease, serine, 8 (PRSS8/prostasin), which acts as an activator of the epithelial sodium channel ENa. Inhibition of such activators may target cystic fibrosis . 257 analogues are included in patent WO2007137080, but without inhibition data.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖