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Compound class: Synthetic organic
Comment: TH5487 is a selective, active-site inhibitor of 8-oxoguanine DNA glycosylase (OGG1) . OGG1 repairs 8-hydroxy-2′-deoxyguanosine (8-oxoG) DNA defects that can be induced by reactive oxygen species (ROS) at sites of inflammation. TH5487 inhibits OGG1-mediated proinflammatory activity in allergic states. In a mouse model of allergic airway inflammation TH5487 reduced NF-κB-mediated expression of proinflammatory cytokines/chemokines and inhibited immune cell recruitment into the lungs with an associated reduction in goblet cell hyperplasia and mucus production .
|Compound class||Synthetic organic|
|GtoPdb PubChem SID||381118894|
|RCSB PDB Ligand||K8Q|
|Search Google for chemical match using the InChIKey||FZLKVWWPFOLPKF-UHFFFAOYSA-N|
|Search Google for chemicals with the same backbone||FZLKVWWPFOLPKF|
|UniChem Compound Search for chemical match using the InChIKey||FZLKVWWPFOLPKF-UHFFFAOYSA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||FZLKVWWPFOLPKF-UHFFFAOYSA-N|
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TH 5487 (links to external site)
Cat. No. 6749