daclatasvir   Click here for help

GtoPdb Ligand ID: 11266

Synonyms: BMS-790052 | BMS790052 | Daklinza®
Approved drug
daclatasvir is an approved drug (EMA (2014), FDA (2015))
Compound class: Synthetic organic
Comment: Daclatasvir is an orally available anti-hepatitis C virus (HCV) drug, It is a direct-acting inhibitor of the non-structural protein 5A (NS5A) replication complex of HCV [1]. Blocking NS5A function inhibits viral RNA replication and virion assembly.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 12
Hydrogen bond donors 4
Rotatable bonds 17
Topological polar surface area 174.64
Molecular weight 738.39
XLogP 5.11
No. Lipinski's rules broken 3
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Canonical SMILES COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc([nH]1)c1ccc(cc1)c1ccc(cc1)c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@H](C(C)C)NC(=O)OC)C(C)C
Isomeric SMILES COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc([nH]1)c1ccc(cc1)c1ccc(cc1)c1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@H](C(C)C)NC(=O)OC)C(C)C
InChI InChI=1S/C40H50N8O6/c1-23(2)33(45-39(51)53-5)37(49)47-19-7-9-31(47)35-41-21-29(43-35)27-15-11-25(12-16-27)26-13-17-28(18-14-26)30-22-42-36(44-30)32-10-8-20-48(32)38(50)34(24(3)4)46-40(52)54-6/h11-18,21-24,31-34H,7-10,19-20H2,1-6H3,(H,41,43)(H,42,44)(H,45,51)(H,46,52)/t31-,32-,33-,34-/m0/s1
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (EMA (2014), FDA (2015))
Withdrawn drug? Yes
WHO Essential Medicine WHO Essential Medicines List (EML) (22nd List, 2021). Access PDF version.
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IUPAC Name Click here for help
methyl N-[(2S)-1-[(2S)-2-[5-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl]phenyl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate
International Nonproprietary Names Click here for help
INN number INN
9483 daclatasvir
Synonyms Click here for help
BMS-790052 | BMS790052 | Daklinza®
Database Links Click here for help
BindingDB Ligand 50387084
CAS Registry No. 1009119-64-5 (source: PubChem)
ChEMBL Ligand CHEMBL2023898
DrugBank Ligand DB09102
DrugCentral Ligand 4875
GtoPdb PubChem SID 434321701
PubChem CID 25154714
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