linzagolix   Click here for help

GtoPdb Ligand ID: 12283

Synonyms: KLH-2109 | KLH2109 | OBE-2109 | OBE2109 | Yselty®
Approved drug
linzagolix is an approved drug (EMA (2022))
Compound class: Synthetic organic
Comment: Linzagolix (KLH-2109) is an orally bioavailable gonadotropin-releasing hormone (GnRH) receptor antagonist [5]. It was developed for potential to downregulate the hypothalamic pituitary-gonadal axis to inhibit the driving force of LH and FSH on estrogen release, as a mechanism to combat the symptoms associated with endometriosis [6], heavy menstrual bleeding or uterine fibroids [1,4].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 7
Topological polar surface area 147.57
Molecular weight 508.06
XLogP 3.96
No. Lipinski's rules broken 0
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Canonical SMILES COc1cc(F)c(cc1OCc1c(OC)ccc(c1F)F)n1c(=O)[nH]c2c(c1=O)c(sc2)C(=O)O
Isomeric SMILES COc1c(c(c(cc1)F)F)COc1c(cc(c(c1)n1c(=O)c2c(scc2[nH]c1=O)C(=O)O)F)OC
InChI InChI=1S/C22H15F3N2O7S/c1-32-14-4-3-10(23)18(25)9(14)7-34-16-6-13(11(24)5-15(16)33-2)27-20(28)17-12(26-22(27)31)8-35-19(17)21(29)30/h3-6,8H,7H2,1-2H3,(H,26,31)(H,29,30)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (EMA (2022))
IUPAC Name Click here for help
3-[5-[(2,3-difluoro-6-methoxyphenyl)methoxy]-2-fluoro-4-methoxyphenyl]-2,4-dioxo-1H-thieno[3,4-d]pyrimidine-5-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
10711 linzagolix
Synonyms Click here for help
KLH-2109 | KLH2109 | OBE-2109 | OBE2109 | Yselty®
Database Links Click here for help
Specialist databases
GPCRdb Ligand linzagolix
Other databases
CAS Registry No. 935283-04-8 (source: WHO INN record)
GtoPdb PubChem SID 473153871
PubChem CID 16656889
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