clazosentan   Click here for help

GtoPdb Ligand ID: 12286

Synonyms: AXV-034343 | AXV034343 | compound 22 [PMID: 9703472] | Pivlaz®
Approved drug
clazosentan is an approved drug (Japan (2022))
Compound class: Synthetic organic
Comment: Clazosentan is a selective endothelin receptor A (ETA) antagonist [1].
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 11
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 208.49
Molecular weight 577.15
XLogP 2.59
No. Lipinski's rules broken 2
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

✖
Canonical SMILES OCCOc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccnc(c1)c1nn[nH]n1
Isomeric SMILES Cc1cnc(cc1)S(=O)(=O)Nc1c(c(nc(n1)c1cc(ncc1)c1n[nH]nn1)OCCO)Oc1ccccc1OC
InChI InChI=1S/C25H23N9O6S/c1-15-7-8-20(27-14-15)41(36,37)32-24-21(40-19-6-4-3-5-18(19)38-2)25(39-12-11-35)29-22(28-24)16-9-10-26-17(13-16)23-30-33-34-31-23/h3-10,13-14,35H,11-12H2,1-2H3,(H,28,29,32)(H,30,31,33,34)
InChI Key LFWCJABOXHSRGC-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (Japan (2022))
IUPAC Name Click here for help
N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-methylpyridine-2-sulfonamide
International Nonproprietary Names Click here for help
INN number INN
8397 clazosentan
Synonyms Click here for help
AXV-034343 | AXV034343 | compound 22 [PMID: 9703472] | Pivlaz®
Database Links Click here for help
Specialist databases
GPCRdb Ligand clazosentan
Other databases
BindingDB Ligand 50066370
CAS Registry No. 180384-56-9 (source: WHO INN record)
ChEMBL Ligand CHEMBL109648
DrugBank Ligand DB06677
GtoPdb PubChem SID 473153874
PubChem CID 6433095
Search Google for chemical match using the InChIKey LFWCJABOXHSRGC-UHFFFAOYSA-N
Search Google for chemicals with the same backbone LFWCJABOXHSRGC
Search PubMed clinical trials clazosentan
Search PubMed titles clazosentan
Search PubMed titles/abstracts clazosentan
UniChem Compound Search for chemical match using the InChIKey LFWCJABOXHSRGC-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey LFWCJABOXHSRGC-UHFFFAOYSA-N