nociceptin/orphanin FQ   Click here for help

GtoPdb Ligand ID: 1681

Abbreviated name: N/OFQ
Species: Human, Mouse, Rat
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2D Structure
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SMILES / InChI / InChIKey
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Canonical SMILES NCCCCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)O)CCC(=O)N)CC(=O)N)C)CC(C)C)CCCCN)CCCNC(=N)N)C)CO)NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(C(O)C)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(Cc1ccccc1)N)C)CCCNC(=N)N
Isomeric SMILES NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CCC(=O)N)CC(=O)N)C)CC(C)C)CCCCN)CCCNC(=N)N)C)CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H]([C@H](O)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)N)C)CCCNC(=N)N
InChI InChI=1S/C79H129N27O22/c1-41(2)33-54(72(122)95-44(5)66(116)103-56(36-59(84)110)73(123)102-53(77(127)128)27-28-58(83)109)104-70(120)49(23-13-15-29-80)100-69(119)52(26-18-32-90-79(87)88)99-65(115)43(4)96-75(125)57(40-107)105-71(121)50(24-14-16-30-81)101-68(118)51(25-17-31-89-78(85)86)98-64(114)42(3)94-61(112)39-93-76(126)63(45(6)108)106-74(124)55(35-47-21-11-8-12-22-47)97-62(113)38-91-60(111)37-92-67(117)48(82)34-46-19-9-7-10-20-46/h7-12,19-22,41-45,48-57,63,107-108H,13-18,23-40,80-82H2,1-6H3,(H2,83,109)(H2,84,110)(H,91,111)(H,92,117)(H,93,126)(H,94,112)(H,95,122)(H,96,125)(H,97,113)(H,98,114)(H,99,115)(H,100,119)(H,101,118)(H,102,123)(H,103,116)(H,104,120)(H,105,121)(H,106,124)(H,127,128)(H4,85,86,89)(H4,87,88,90)/t42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-/m0/s1
InChI Key PULGYDLMFSFVBL-SMFNREODSA-N
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Neuropeptides
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
PNOC prepronociceptin Human prepronociceptin (PPNOC) nocistatin, PPNOC
Pnoc prepronociceptin Mouse prepronociceptin (PPNOC) N23K, N/OFQ, Npnc1, OFQ/N, proorphanin
Pnoc prepronociceptin Rat prepronociceptin (PPNOC) N23K, neuropeptide nociceptin 1, nociceptin, Npnc1, orphanin FQ, prepronociceptin, Prepronociceptin (neuropeptide nociceptin) (N23K)
Database Links Click here for help
BindingDB Ligand 21842
CAS Registry No. 170713-75-4
ChEMBL Ligand CHEMBL396460
Ensembl Gene ENSG00000168081 (Hs), ENSRNOG00000014231 (Rn), ENSMUSG00000045731 (Mm)
GtoPdb PubChem SID 135651822
Human Protein Atlas ENSG00000168081 (Hs)
PubChem CID 16131448
Search Google for chemical match using the InChIKey PULGYDLMFSFVBL-SMFNREODSA-N
Search Google for chemicals with the same backbone PULGYDLMFSFVBL
UniChem Compound Search for chemical match using the InChIKey PULGYDLMFSFVBL-SMFNREODSA-N
UniChem Connectivity Search for chemical match using the InChIKey PULGYDLMFSFVBL-SMFNREODSA-N
UniProtKB Q62923 (Rn), Q64387 (Mm), Q13519 (Hs)
Wikipedia Nociceptin

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Nociceptin
Cat. No. 0910