mecamylamine   Click here for help

GtoPdb Ligand ID: 3990

Approved drug
mecamylamine is an approved drug (FDA (2013))
Compound class: Synthetic organic
Comment: Mecamylamine is a non-selective, non-competitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is often used as a research tool for its action as a ganglionic blocker (or ganglioplegic).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 12.03
Molecular weight 167.17
XLogP 2.66
No. Lipinski's rules broken 0
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Canonical SMILES CNC1(C)C2CCC(C1(C)C)C2
Isomeric SMILES CNC1(C)C2CCC(C1(C)C)C2
InChI InChI=1S/C11H21N/c1-10(2)8-5-6-9(7-8)11(10,3)12-4/h8-9,12H,5-7H2,1-4H3
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2013))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
542 mecamylamine
Database Links Click here for help
CAS Registry No. 60-40-2 (source: Scifinder)
ChEMBL Ligand CHEMBL267936
DrugBank Ligand DB00657
DrugCentral Ligand 1646
GtoPdb PubChem SID 178100816
PubChem CID 4032
Search Google for chemical match using the InChIKey IMYZQPCYWPFTAG-UHFFFAOYSA-N
Search Google for chemicals with the same backbone IMYZQPCYWPFTAG
Search PubMed clinical trials mecamylamine
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UniChem Compound Search for chemical match using the InChIKey IMYZQPCYWPFTAG-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey IMYZQPCYWPFTAG-UHFFFAOYSA-N
Wikipedia Mecamylamine