Abbreviated name: TBZ
Synonyms: Nitoman® | Revocon® | Ro-19569
tetrabenazine is an approved drug (FDA (2008))
Compound class:
Synthetic organic
Comment: Tetrabenazine is an inhibitor of the vesicular monoamine transporter type 2 (VMAT2; SLC18A2). Tetrabenazine was the first dopamine-depleting drug approved in the US for the treatment of Huntington's disease. The potential for using dopamine-depleters to manage hyperkinetic movement disorders is reviewed in [2]. Since the approval of tetrabenazine, the deuterated analogue deutetrabenazine has been a granted marketing authorisation by the FDA (April 2107), and valbenazine is in clinical trial for tardive dyskinesia and Tourette syndrome
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Synthetic organic |
Approved drug? | Yes (FDA (2008)) |
IUPAC Name |
9,10-dimethoxy-3-(2-methylpropyl)-1H,2H,3H,4H,6H,7H,11bH-pyrido[2,1-a]isoquinolin-2-one |
International Nonproprietary Names | |
INN number | INN |
1056 | tetrabenazine |
Synonyms |
Nitoman® | Revocon® | Ro-19569 |
Database Links | |
CAS Registry No. | 58-46-8 (source: Scifinder) |
ChEMBL Ligand | CHEMBL117785 |
DrugBank Ligand | DB04844 |
GtoPdb PubChem SID | 178101536 |
PubChem CID | 6018 |
Search Google for chemical match using the InChIKey | MKJIEFSOBYUXJB-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | MKJIEFSOBYUXJB |
Search PubMed clinical trials | tetrabenazine |
Search PubMed titles | tetrabenazine |
Search PubMed titles/abstracts | tetrabenazine |
UniChem Compound Search for chemical match using the InChIKey | MKJIEFSOBYUXJB-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | MKJIEFSOBYUXJB-UHFFFAOYSA-N |
Wikipedia | Tetrabenazine |